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KMID : 1189420070200010177
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2007 Volume.20 No. 1 p.177 ~ p.194
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Attenuation of airway hyperreactivity (AHR) and inflammation by water extract of Rubus coreanus M IQ (WRCM)
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Park Min-Cheol
Kim Kyung-Jun
Lee Ho-Sub
Cho Eun-Hee
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Abstract
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Fructus of Rubus coreanus . (FRCM) has been used for stuttering urination, prostate gland disease, and impotence in Korean traditional medicine. Water extract of FRCM (WFRCM) treatment significantly attenuated airway hyperreactivity (AHR). Airway recruitment of leukocytes and eosinophils was also markedly reduced by WFRCM administration, suggesting that WFRCM can alleviate the airway inflammation. However, the level of cytokine (IL-4, IL-5, and IL-13) in bronchoalveolar lavage fluid (BALF) and lung was not different compared with positive control. WFRCM reduced the number of draining lymph node cells during OVA-induced allergic asthma. I further examined transcription level of cytokine in lung. WFRCM treatment reduced IL-4 and IL-13 mRNA in lung and inhibited IgE and IgG1 but not IgG2a. My data suggest that WFRCM attenuates OVA-induced allergic asthma through inhibition of Th2 cell response.
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KEYWORD
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FructusofRubuscoreanusMIQ, airwayhyperreactivity, airwayinflammation, eosinophils, cytokines, IgE
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